Obesity Models

RenaSci offers the following different animal models of obesity:

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Energy intake and output

Factors involved in the control of food intake and body weight:

• Acute and chronic food intake
• Body weight assessment
• Satiety profiling
• Microstructural feeding analysis
• PICA (kaolin) ingestion 
• Conditioned taste aversion
• Metabolic rate measurement by indirect calorimetry
• Meal pattern (locomotor activity analysis) 

Rodent models of overweight and obesity

• Characteristics of Dietary-Induced Obesity (DIO) in rats and mice 

Drug-induced weight gain

• Neuroleptic-induced weight gain 
• Rosiglitazone-induced weight gain

Outcome measures

• Body composition analysis 
• Faecal fat analysis
• Energy balance determination
• Non-invasive body fat determination (TOBEC) 
• Plasma indices of glycaemic control and metabolic status 
• We offer many standard assay kits 
• Effect of weight-loss drugs on comorbid risk factors 
• DMPK

In vitro and ex vivo techniques

• Mitochondrial respiration / membrane potential / ion flux 
• Lipolysis in adipose tissue explants 
• Oxygen consumption in cell lines

New models

• JAX mouse model of diet-induced metabolic syndrome 
• JAX mouse model of Type 2 diabetes