Diabetes Models

RenaSci offers a variety of models of diabetes and /or insulin resistance for the evaluation of compounds with antidiabetic activity:

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Insulin resistance (IR)

• Dietary-induced obese (DIO) rats and mice 
• High fat-fed rats 
• Aged rats maintained on a high fat diet
• Glucocorticoid induced IR 
• Safflower oil-induced IR
• JAX model of metabolic syndrome 

Type 2 diabetes (T2D)

• Zucker rats 
• ob/ob and db/db mice 
• Streptozotocin-induced T2D (in development)
• JAX model of T2D 

Drug-induced weight gain

• Rosiglitazone-induced weight gain 

In vivo techniques

• glucose challenge test 
• Insulin hypoglycaemia test
• Hyperinsulinaemic-euglycaemic clamps (in development)
• DMPK

In vitro techniques

• Isolated pancreatic islets 
• Lipolysis in adipose tissue explants 

Biomarkers

• Plasma indices of glycaemic control and metabolic status
  - we offer many standard assay kits
  - effect of weight-loss drugs on comorbid risk factors 

Immunohistochemistry and Histopathology

• Islet immunostaining for insulin and glucagon 
• Histology and histopathological analysis of tissue samples