Ex Vivo Receptor Binding

Biospace β imager

RenaSci employs the Biospace β-Imager technology to provide fast screening of compounds to identify receptor binding sites, quantify receptor occupancy or CNS drug penetration.

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Quantitative autoradiography

• comprehensive service to perform complete studies
• autoradiography-only service to read slides provided by clients

Benefits

• Detects low energy β-emitting isotopes ³H, ¹⁴C, ³²P, ³⁵S, ³³P, ¹²⁵I
• Fast detection of radioactivity – hours rather than days or weeks
• High (0.007 cpm/mm2) sensitivity to tritium
• 50 μm spatial resolution
• Digital real-time imaging to optimise exposure

Experimental options

• Rats or mice
• All routes of administration
• Homogenates
• Brain slices
• ³H or ¹²⁵I ligands

Assay capabilities

• Uptake sites (NET, DAT, SERT)
• Dopamine receptors (D₃, D₂)
• Serotonin receptors (5-HT_1A, 5-HT₂, 5-HT₆)
• MCH receptors
• CB₁ receptors
• Novel assays developed