Neurochemical Fingerprinting
Neurochemical Fingerprinting is a rapid ex vivo screen in mice. It can be used to characterise the mode of action of indirectly-acting dopamine mimetic drugs. The assay has been validated by studying the effects of drugs that increase synaptic dopamine by different mechanisms on levels of dopamine and its metabolites in the striatum and prefrontal cortex of the same animals as these brain regions have different presynaptic mechanisms for regulating dopamine release and metabolism. It can also be used to demonstrate that the test substance has little effect on the dopaminergic system in vivo.
