Glucocorticoid-induced Insulin Resistance

Glucocorticoid-induced Insulin Resistance


Oversecretion of glucocorticoids (eg in Cushing’s syndrome) can produce insulin resistance in the clinic. This has led to the development of glucocorticoid-induced insulin resistance in rats and mice as a screen for potential antidiabetic activity.

We have shown that sub-chronic administration of a glucocorticoid such as cortisone once a day significantly increased plasma glucose and insulin levels in rats. This model can be used to evaluate the antidiabetic potential of novel drugs such as selective glucocorticoid antagonists or inhibitors of 11β hydroxysteroid dehydrogenase (11βHSD), enzymes which catalyze the conversion of cortisone to cortisol (and vice versa) and therefore regulate the access of glucocorticoids to steroid receptors.

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Hunt et al. 2015. Evaluation of the antidiabetic effect of novel selective glucocorticoid antagonists in a model of cortisone-induced diabetes. Abstract No. 1240-P. American Diabetes Association 75th Scientific Sessions, Boston, Massachusetts, USA, 5th-9th June, 2015.