Metabolic Parameters and Biomarkers
A variety of metabolic parameters and biomarkers can be measured in plasma and whole blood using standard commercially-available kits and reagents. Samples can be taken before, during and at the end of chronic studies in normal rats or mice or animal models of obesity/diabetes. Urinary glucose excretion can be measured at appropriate time-points during a study to see whether compounds with relevant pharmacology produce glycosuria or whether test drugs can reduce glycosuria in animal models of overt type 2 diabetes and urine can be assayed for markers of kidney damage such as microalbuminuria, creatinine and total protein.
At the end of studies, tissue levels of various metabolic parameters eg pancreatic insulin and liver triglycerides or total cholesterol can be determined. We also offer novel assay development by our experienced biochemists (for transfer to your own labs if required) and can analyse samples collected from your own experiments.
