RenaSci

DEXA

DEXA of DIO mouse

 

RenaSci has recently acquired a Lunar PIXImus Densitomer and now offers bone and tissue composition analysis in mice by dual-energy X-ray absorptiometry (DEXA). We have validated the  DEXA technology by demonstrating excellent correlation between the fat content of dietary-induced obese mice determined by DEXA with results obtained using gold standard chemical extraction techniques.

Carcass fat determined by DEXA and chemical analysis

Measures provided by the DEXA densitometer include :-

 

•     fat mass (%)

•     fat mass (g)

•     total tissue mass (g)

•     lean mass (g)

•     bone mineral density (g/cm2)

•     bone mineral content (g)


The main advantage of DEXA is that it can be performed in live animals. This means that we can now provide longitudinal measurements of bone and tissue composition throughout chronic mouse studies. Furthermore, data is provided within 5 min, therefore DEXA is much quicker and cheaper than conventional body composition analysis.


Longitudinal Measurement of Fat and Lean Mass in DIO Mice by DEXA

Longitudinal Measurement of Bone Mineral Density and Content in DIO Mice by DEXA

 

DEXA can be conducted in our mouse models of obesity and diabetes or on carcasses from your own studies.

 

Please contact us for further information about DEXA.

 

Posters

 

Burkey et al. 2017. The MetAP2 inhibitor ZGN-1061 improves glycaemia in high-fat diet-induced obese mice. Program No. 845. 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD), Lisbon, Portugal, 11th to 15th September, 2017.