High Fat Fed “Overweight” Rat Model
Acute, sub-chronic or chronic feeding studies can be performed in normal, outbred male rats maintained on a high fat diet for two weeks prior to the study. The male rats are in an active growth phase and rapidly gain weight on the high fat diet but are not obese. The high fat fed “overweight” rat model is an excellent polygenic screen for investigating the efficacy and tolerability of drugs before chronic feeding studies in dietary-induced obese rats. It does not include a lengthy induction of obesity period therefore animals are readily available.
