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High Fat Fed "Overweight" Rat Model

High Fed Fed Overweight Rat

 

Feeding studies can be performed in normal, outbred rats maintained on a high fat diet for two weeks prior to the study. Male rats are normally used for this assay. The animals are in an active growth phase and rapidly gain weight on the high fat diet but are not obese. The high fat fed “overweight” rat model is an excellent polygenic screen for investigating the efficacy and tolerability of drugs before chronic feeding studies in dietary-induced obese rats. It does not include a lengthy induction of obesity period therefore animals are readily available.

 

Key features of the high fat fed 'overweight' rat model are :-

 

     •     Acute, sub-chronic or chronic feeding studies
     •     Body weight and food and water intake measurements
     •     Blood and tissue-sampling for pharmacokinetic analysis or to determine levels of
           metabolic parameters/other biomarkers
     •     Fat pad weights/body composition analysis
     •     Necropsy and gross post mortem analysis
     •     Ex vivo binding to confirm brain penetration/mode of action

 

Studies in high fat fed rats can be customised to meet the specific requirements of each client and include advice on experimental design, statistical analysis by a qualified statistician, fully audited data pack and written reports to regulatory standard if required.


High Fat Fed Overweight Rat Model

Measurement of Food Intake in High Fat Fed Overweight Rats

 

Please contact us for further information on our high fat fed ‘overweight’ rat model.

 

Posters

 

Henderson et al. 2011. Identification of the 5-HT6 antagonist AMR-SIX-1 for the treatment of obesity. Keystone Symposium, Obesity, Keystone, Colorado, 12th-17th January 2011.

 
Shacham et al. 2006. PRX-07034, a potent and selective 5-HT6 receptor antagonist, reduces food intake and body weight in dietary-induced obese rats. Program No. 62.10. Society for Neuroscience Meeting, Atlanta, Georgia, 14th-18th October, 2006.

 

Manuscripts

 

Cheetham and Jackson 2012. Rodent models to evaluate anti-obesity drugs. In: TRP Channel Targets for Drugs and Toxins, Volume II. A Szallasi and T Bíró (Eds), Methods in Pharmacology and Toxicology, Volume I, Springer Protocols, Humana Press, pp351-376.

 

Vickers et al. 2011. The utility of animal models to evaluate novel anti-obesity agents. Br J Pharmacol 164: 1248-1262. [PubMed]