Inhibition of Gastric Emptying
Inhibition of gut motility has been linked to satiety and reduced food intake therefore we have developed the phenol red recovery model in mice to evaluate the ability of drugs to inhibit gastric emptying. The model has been validated at RenaSci using the GLP-1 agonist, exenatide (exendin-4) and the opioid agonist, loperamide. Both compounds significantly decreased % gastric emptying compared to control animals.
