Lipolysis
Lipolysis, the hydrolysis of triglycerides to glycerol and free fatty acids, can be measured directly using isolated adipose tissue explants from normal, high-fat fed rats or mice or genetic models of obesity/diabetes. The effect of acute application of drugs on lipolysis in vitro can be determined or lipolysis can be measured ex vivo in tissues taken from animals following acute or chronic drug administration. Glycerol is normally measured as an indicator of lipolysis, although other markers are possible.
