RenaSci

Adriamycin-induced Nephropathy Model of CKD 14/06/2017 03:15

We have recently established the adriamycin-induced nephropathy mouse model of chronic kidney disease.

Adriamycin is a drug used in cancer chemotherapy. When given to animals it produces glomerular sclerosis and changes in tubulo-interstitial histology that mirror the pathological changes seen in human CKD. These changes are robust and reproducible and occur within days following intravenous administration of adriamycin. They are accompanied by impaired kidney function as shown by marked increases in urinary albumin excretion and in the urinary albumin/creatinine ratio.

The adriamycin-induced nephropathy model can be used to evaluate the efficacy of new drugs to treat chronic kidney disease. This model complements our existing animal models of diabetic nephropathy and has the advantage that it is of much shorter duration as it does not depend on the development of diabetes.

Please click here to see our adriamycin-induced nephropathy flyer.