RenaSci

New Nicotine Self-administration Procedure

06/04/2016 10:40

We have recently validated a nicotine intravenous self-administration model in rats using fixed and progressive ratio schedules of reinforcement. We found that the relative reinforcing effect of nicotine equals that of a highly reinforcing dose of heroin.

This model can now be used to assess the abuse liability of novel CNS drugs with nicotinic mechanisms or to evaluate novel interventions to treat nicotine addiction (eg for smoking cessation).

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