RenaSci

Abuse & Dependence/CNS Publications

Manuscripts

Heal DJ et al. Dopamine and μ-opioid receptor dysregulation in the brains of binge-eating female rats - possible relevance in the psychopathology and treatment of binge-eating disorder. J. Psychopharmacol. 2017 Apr 1. doi: 10.1177/0269881117699607. [Epub ahead of print] [PubMed]

Vickers SP et al. Investigation of impulsivity in binge-eating rats in a delay-discounting task and its prevention by the d-amphetamine prodrug, lisdexamfetamine. J Psychopharmacol. 2017 Feb 1. doi: 10.1177/0269881117691672. [Epub ahead of print] [PubMed]

Pillidge K et al. The NK1R-/- mouse phenotype suggests that small body size, with a sex- and diet-dependent excess in body mass and fat, are physical biomarkers for a human endophenotype with vulnerability to attention deficit hyperactivity disorder. J Psychopharmacol. 30: 848-855, 2016. [PubMed]

Heal DJ et al. Lisdexamfetamine reduces the compulsive and perseverative behaviour of binge-eating rats in a novel food reward/punished responding conflict model. J Psychopharmacol. 30: 662-675, 2016  [PubMed]

Vickers SP et al. Effects of lisdexamfetamine in a rat model of binge-eating. J Psychopharmacol. 29: 1290-1307, 2015. [PubMed]

Hutson PH et al. The effects in rats of lisdexamfetamine in combination with olanzapine on mesocorticolimbic dopamine efflux, striatal dopamine D2 receptor occupancy and stimulus generalization to a d-amphetamine cue .Neuropharmacology 101: 24-35, 2015. [PubMed]

Calderon S et al.  Chapter 10. Regulatory framework and guidance to the evaluation of the abuse liability of drugs in the United States and Europe. In: Nonclinical Assessment of Abuse Potential for New Pharmaceuticals, 1st Edition. C Markgraf, T Hudzik and D Compton (Eds). Academic Press, Elsevier, pp 245-268, 2015. 

Heal DJ et al. Dopamine reuptake transporter (DAT) "inverse agonism" - A novel hypothesis to explain the enigmatic pharmacology of cocaine. Neuropharmacology 87: 19-40, 2014. [PubMed]

Pillidge K et al. Atomoxetine reduces hyperactive/impulsive behaviours in neurokinin-1 receptor 'knockout' mice. Pharmacol Biochem Behav 127: 56-61, 2014. [PubMed]

Pillidge K et al. The behavioural response of NK1R-/- mice to guanfacine resembles its clinical profile in treatment of ADHD. Br J Pharmacol 171: 4785-4796, 2014. [PubMed]

Ash ES et al. Contrasting changes in extracellular dopamine and glutamate along the rostrocaudal axis of the anterior cingulate cortex of the rat following an acute d-amphetamine or dopamine challenge. Neuropharmacology 87: 180-187, 2014.  [PubMed] 

Rowley HL et al. Differences in the neurochemical and behavioural profiles of lisdexamfetamine, methylphenidate and modafinil revealed by simultaneous dual-probe microdialysis and locomotor activity measurements in freely-moving rats. J Psychopharmacol 28(3): 254-269, 2014. [PubMed] 

Bolea-Alamañac B et al. Evidence-based guidelines for the pharmacological management of attention deficit hyperactivity disorder: update on recommendations from the British Association for Psychopharmacology. J Psychopharmacol 28(3): 179-203, 2014. [PubMed]

Heal DJ et al. A preclinical evaluation of the discriminative and reinforcing properties of lisdexamfetamine in comparison to D-amfetamine, methylphenidate and modafinil. Neuropharmacology 73: 348-358, 2013. [PubMed]

Heal DJ et al. Amphetamine, past and present - a pharmacological and clinical perspective. J Psychopharmacol 27(6): 479-496, 2013. [PubMed]

Heal DJ et al. Metabolic consequences of antipsychotic therapy: preclinical and clinical perspectives on diabetes, diabetic ketoacidosis, and obesity. In: Current Antipsychotics, Handb Exp Pharmacol Vol 212, G Gross and MA Geyer (Eds), Springer, pp135-164, 2012. [PubMed]

Rowley HL et al. Lisdexamfetamine and immediate release d-amfetamine - Differences in pharmacokinetic/pharmacodynamic relationships revealed by striatal microdialysis in freely-moving rats with simultaneous determination of plasma drug concentrations and locomotor activity. Neuropharmacology 63(6): 1064-1074, 2012. [PubMed]

Kennett A et al. Pharmacological differences between rat frontal cortex and hippocampus in the nicotinic modulation of noradrenaline release implicate distinct receptor subtypes. Nicotine Tob Res 14(11): 1339-1345, 2012. [PubMed]

Heal DJ et al. ADHD: Current and future therapeutics. Curr Top Behav Neurosci 9: 361-390, 2012. [PubMed]

Heal DJ et al. The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safety. Neuropharmacology 57: 608-618, 2009. [PubMed]

Watson J et al. Receptor occupancy and brain free fraction. Drug Metab Dispos 37: 753-760, 2009. [PubMed]

Heal DJ et al. New perspectives from microdialysis studies in freely moving spontaneously hypertensive rats on the pharmacology of drugs for the treatment of ADHD. Pharmacol Biochem Behav 90: 184-197, 2008. [PubMed]

Heal DJ and Pierce D. Methylphenidate and its isomers: their role in the treatment of attention-deficit hyperactivity disorder using a transdermal delivery system. CNS Drugs 20: 713-738, 2006. [PubMed]

Posters

Heal DJ et al. Investigation of the discriminative and reinforcing properties of the κ-opioid receptor agonist CR845 in rats. Program No. 819.04. Presented at the Society for Neuroscience Meeting, San Diego, California, USA, 12th-16th November, 2016. View poster

Smith SL et al. Comparison of the reinforcing effects of nicotine versus heroin, remifentanil and cocaine with rat intravenous self-administration. Program No. 549.10. Presented at the Society for Neuroscience Meeting, San Diego, California, USA, 12th-16th November, 2016. View poster

Gill D. et al. Determination of the concentrations of d-amphetamine, neurotransmitters and various metabolites in microdialysates taken from the brains of freely-moving rats. Program No. 498.13. Presented at the Society for Neuroscience Meeting, San Diego, California, USA, 12th-16th November, 2016. View poster

Rowley HL. et al. Comparison of Synaptech versus CMA probes for the quantification of extracellular acetylcholine, dopamine and its metabolites by cerebral microdialysis in freely-moving rats. Program No. 846.15. Presented at the Society for Neuroscience Meeting, San Diego, California, USA, 12th-16th November, 2016. View poster

Menzaghi F et al. Preclinical and clinical assessments of the abuse potential of the kappa-opioid receptor agonist CR845 suggest low abuse potential. Poster No. 122. Presented at PAINWeek 2016, The Cosmopolitan of Las Vegas, Las Vegas, Nevada, USA, 6th-10th September, 2016. View poster

Heal DJ et al. A preclinical evaluation of the potential of the κ-opioid receptor agonist CR845 to induce tolerance and a syndrome of dependence on withdrawal. Poster No. 0077. Presented at the Joint Meeting of the Safety Pharmacology Society, Japanese Safety Pharmacology Society and Canadian Society of Pharmacology and Therapeutics, Vancouver, British Columbia, Canada, 18th-21st September, 2016. View poster

Oakley GE et al. Comparison of the relative reinforcing efficacy of heroin, morphine and remifentanil using fixed and progressive ratio schedules of reinforcement in rat self-administration. Poster No. 059P. Presented at Pharmacology 2015 (Annual Meeting of the British Pharmacological Society), London, UK, 15th-17th December 2015. View poster

Hutson PH et al. Preclinical evidence to demonstrate that lisdexamfetamine prevents impulsivity in binge eating. Poster No. M46. Presented at the 54th Annual Meeting of the American College of Neuropsychopharmacology (ACNP), The Diplomat Resort & Spa, Hollywood, Florida, USA, 6th-10th December, 2015. View poster

Tarazi FI et al. Reduced expression of GAD65/67 mRNA and dopamine Dand Dreceptors in binge-eating rats. Poster No. M48. Presented at the 54th Annual Meeting of the American College of Neuropsychopharmacology (ACNP), The Diplomat Resort & Spa, Hollywood, Florida, USA, 6th-10th December, 2015. View poster

Vickers SP et al. Binge-eating rats show marked impulsivity in a delay discounting task. Program No. 723.09. Presented at the Society for Neuroscience Meeting, Chicago, Illinois, USA, 17th-21st October, 2015. View poster

Hutson PH et al. Preclinical evidence showing that lisdexamfetamine (LDX) prevents compulsive and perseverative behaviour associated with binge-eating. Poster Session II, No. W56. Presented at the Annual Meeting of the American Society of Clinical Psychopharmacology (ASCP), Miami, Florida, USA, 22nd-25th June, 2015. View poster

Rowley HL et al. Simultaneous determination of the effects of methamphetamine on GABA, glutamate and monoamines by microdialysis in the prefrontal cortex and hippocampus of rats. Abstract No 553. Presented at the 77th Annual Scientific Meeting of the College on Problems of Drug Dependence (CDPP), Phoenix, Arizona, USA, 13th-18th June, 2015. View poster

Heal DJ et al. Evaluation of remifentanil and morphine as reinforcers in a rat intravenous self-administration procedure. Abstract No 266. Presented at the 77th Annual Scientific Meeting of the College on Problems of Drug Dependence (CPDD), Phoenix, Arizona, USA, 13th-18th June, 2015. View poster

Wonnacott S et al. α7 nicotinic receptor antagonism selectively reduces reinstatement to morphine conditioned place preference. Abstract No. 100.  Presented at the International Narcotics Research Conference (INRC), Phoenix, Arizona, USA, 15th-19th June, 2015. View poster

Wright VL et al. Evidence for the involvement of hippocampal α7 nicotinic acetylcholine receptors in morphine primed reinstatement to conditioned place preference. Abstract No. 101. Presented at the International Narcotics Research Conference (INRC), Phoenix, Arizona, USA, 15th-19th June, 2015. View poster

Eyerman DJ et al. Combinations of buprenorphine and samidorphan modulate glutamatergic transmission in the medial prefrontal cortex and ventral hippocampus of male Wistar rats. Poster No. W189. Presented at the 53rd Annual Meeting of the American College of Neuropsychopharmacology (ACNP), Phoenix, Arizona, USA, 7th-11th December, 2014. View poster

Heal DJ et al. Binge-eating behaviour in rats induces changes in dopamine and opioid receptor binding in the brain. Poster No. M12. Presented at the 53rd Annual Meeting of the American College of Neuropsychopharmacology (ACNP), Phoenix, Arizona, USA, 7th-11th December, 2014. View poster

Hutson PH et al. Lisdexamfetamine-induced suppression of binge-eating in rats is attentuated by the α1-adrenoceptor antagonist, prazosin. Presented at the 53rd Annual Meeting of the American College of Neuropsychopharmacology (ACNP), Phoenix, Arizona, USA, 7th-11th December, 2014. View poster

Cheetham SC et al. Binge-eating behaviour produces alterations in dopaminergic neurochemistry in the brains of rats. Program No. 233.04. Society for Neuroscience Meeting, Washington, DC, USA. 15th-19th November, 2014. View poster

Heal DJ et al. Monoaminergic interactions between lisdexamfetamine and duloxetine determined by dual-probe intracerebral microdialysis in freely-moving rats. Program No. 517.15. Society for Neuroscience Meeting, Washington, DC, USA. 15th-19th November, 2014. View poster

Schumann J et al. Metadoxine - a novel synaptic transmission modulator with low abuse potential in development for attention-deficit hyperactivity disorder (ADHD). Program No. 2.30. Presented at the 61st Annual Meeting of the American Academy of Child and Adolescent Psychiatry (AACAP), San Diego, California, USA, 20th-25th October, 2014. View poster

Hutson PH et al. A dual-probe microdialysis investigation of the interaction between lisdexamfetamine and S-citalopram on CNS monoamines - evidence for synergistic augmentation of serotonin and dopamine efflux. Presented at the Annual Meeting of the American Society of Clinical Psychopharmacology (ASCP, formerly NCDEU), Hollywood, Florida, USA, 16th-19th June, 2014. View poster

Heal DJ et al. A progressive ratio determination of the relative reinforcing effect of methylphenidate versus cocaine by intravenous self-administration testing in rats. Abstract No W186. Presented at the 52nd Annual Meeting of the American College of Neuropsychopharmacology (ACNP), Hollywood, Florida, USA, 8th-12th December 2013. Please contact us for a copy of the poster.

Heal DJ et al. Profiles of lisdexamfetamine, methylphenidate and modafinal as positive reinforcers in rats trained to self-administer cocaine. Program No 142.09. Society for Neuroscience Meeting, San Diego, California, USA, 9th-13th November 2013. View poster

Vickers SP et al. Effect of lisdexamfetamine in a rat model of binge-eating disorder. Program No 236.03. Society for Neuroscience Meeting, San Diego, California, USA, 9th-13th November 2013. View poster 

Heal DJ et al. Subjective and reinforcing effects of modafinil in rats. Abstract No 236. Presented at the 75th Annual Scientific Meeting of the College on Problems of Drug Dependence (CPDD), San Diego, California, USA, 15th-20th June 2013.  View poster

Rowley HL et al. A microdialysis and behavioural investigation of modafinil in freely-moving rats. Abstract No 547. Presented at the 75th Annual Scientific Meeting of the College on Problems of Drug Dependence (CPDD), San Diego, California, USA, 15th-20th June 2013. View poster 

Sood P et al. Profound suppression of noradrenaline, dopamine and 5-HT turnover in various regions of rat brain evoked by the alpha2-adrenoceptor agonist, clonidine. British Association for Psychopharmacology  Summer Meeting, Harrogate, UK, 22nd-25th July 2012. Abstract No TE06. J. Psychopharm. Vol 26, Supplement to Issue 8, August 2012. View poster

Heal DJ et al. Profiles of lisdexamfetamine, methylphenidate and modafinil in rats trained to discriminate d-amfetamine from saline. British Association for Psychopharmacology  Summer Meeting, Harrogate, UK, 22nd-25th July 2012. Abstract No TI02. J. Psychopharm. Vol 26, Supplement to Issue 8, August 2012. View poster

Rowley HL et al. A microdialysis and behavioural comparison of lisdexamfetamine, methylphenidate and modafinal in freely-moving rats. British Association for Psychopharmacology Summer Meeting, Harrogate, UK, 22nd-25th July 2012. Abstract No TI03. J. Psychopharm. Vol 26, Supplement to Issue 8, August 2012. View poster

Heal DJ et al. Profiles of lisdexamfetamine and methylphenidate in rats trained to discriminate d-amfetamine from saline. Presented at the NCDEU Meeting, Arizona Biltmore Resort & Spa, Phoeniz, Arizona, USA, 29th May -1st June, 2012.  View poster

Rowley HL et al. A microdialysis and behavioural comparison of lisdexamfetamine and methylphenidate in freely-moving rats. Presented at the NCDEU Meeting, Arizona Biltmore Resort & Spa, Phoeniz, Arizona, USA, 29th May -1st June, 2012.  View poster

Jackson HC et al. Comparison of the effects of equivalent doses of lisdexamfetamine dimesylate and d-amphetamine on extracellular concentrations of striatal dopamine, locomotor activity and plasma d-amphetamine concentrations in freely-moving rats. Program No 775.23. Society for Neuroscience Meeting, Washington, DC, USA, 12th-16th November 2011. View poster

Rowley HL et al. Lisdexamfetamine dimesylate versus d-amphetamine - Hysteresis analyses of the relationships between extracellular striatal dopamine and locomotor activity measured in freely-moving rats. Program No 775.11. Society for Neuroscience Meeting, Washington, DC, USA, 12th-16th November 2011. View poster

Cheetham SC et al. Differences in presynaptic mechanisms of the ADHD drugs, d-amphetamine and methylphenidate, revealed by "neurochemical fingerprinting”: correlations between dopamine neurochemistry and behavioural function. Program No 669.21. Society for Neuroscience Meeting, San Diego, California, USA, 13th-17th November 2010.  View poster

Heal DJ et al. Further validation of “neurochemical fingerprinting” to characterise drugs with different presynaptic dopaminergic mechanisms: comparison with in vivo microdialysis. Program No. 669.22. Society for Neuroscience Meeting, San Diego, California, USA, 13th-17th November 2010.  View poster

Cheetham SC et al. Sequential determination of limbic and striatal behavioural function and dopamine neurochemistry in C57/BL6 mice. Program No. 843.16. Society for Neuroscience Meeting, Chicago, Illinois, USA, 17th-21st October 2009.  View poster

Heal DJ et al. “Neurochemical fingerprinting” as a rapid technique to discriminate between drugs with different presynaptic dopaminergic mechanisms. Program No. 421.2. Society for Neuroscience Meeting, Chicago, Illinois, USA, 17th-21st October 2009.  View poster

Viggers, JA et al. Development and validation of a radioligand receptor binding assay for MCH1 receptors using [3H]AMR-MCH-1 in vitro and ex vivo. Program No. 584.27. Society for Neuroscience Meeting, Washington, DC, USA, 15th-19th November 2008.  View poster

Heal DJ et al. Demonstration of the relationship between the in vivo dopamine efflux, behaviour and drug pharmacokinetics.  Poster at a College on the Problems of Drug Dependence (CPDD) Meeting, Washington, DC, USA, 27th-28th October 2008.  View poster

Cheetham SC et al. The SH rat model of ADHD has profoundly different catecholaminergic responses to amphetamine’s enantiomers compared with Sprague-Dawleys.  Program No. 386.14 Society for Neuroscience Meeting, San Diego, California, USA, 3rd-7th November 2007. View poster

Heal DJ et al.  A comparison using in vivo microdialysis of the catecholamine profiles of dexamphetamine and methylphenidate in an animal model of ADHD. Program No 386.7. Society for Neuroscience Meeting, San Diego, California, USA, 3rd-7th November 2007.  View poster

Babbs AJ et al. PSN S1 and PSN S2 are novel 5-HT1A agonists and norepinephrine reuptake inhibitors which show anti-feeding efficacy and superior cardiovascular safety to sibutramine in rats. Program No. 62.3. Society for Neuroscience Meeting, Atlanta, Georgia, USA, 14th-18th October 2006. View poster

Heal DJ et al.  Characterisation of the catecholaminergic profiles of methyphenidate and its enantiomers in an animal model of ADHD by in vivo microdialysis. Program No. 97.4. Society for Neuroscience Meeting, Atlanta, Georgia, USA, 14th-18th October 2006.  View poster

Cheetham SC et al. Ex vivo occupancy as a technique to assess drug actions at multiple targets. Program No. 447.6. Society for Neuroscience Meeting, Washington, DC, USA, 12th-16th November 2005.  View poster

Rowley HL et al. Effects of HT-2157, a Galanin-3 receptor antagonist, on extracellular levels of 5-HT in various brain regions of freely-moving rats. Abstract No.167P. Proceedings of the BPS Winter meeting, London, UK, December 2005.  View poster

Rowley HL et al. The HT-2157 induced increase in extracellular 5-HT levels in the frontal cortex of freely-moving rats is modulated by 5 HT1A receptors. Abstract No.165P. Proceedings of the BPS Winter meeting, London, UK, December 2005.  View poster