CNS Techniques/Drug Abuse Testing
Manuscripts
Heal DJ et al. ADHD: Current and future therapeutics. Curr Top Behav Neurosci 9: 361-390, 2012.
Heal DJ et al. The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safety. Neuropharmacology 57: 608-618, 2009.
Watson J et al. Receptor Occupancy and Brain Free Fraction. Drug Metab Dispos 37: 753-760, 2009.
Heal DJ et al. New perspectives from microdialysis studies in freely moving spontaneously hypertensive rats on the pharmacology of drugs for the treatment of ADHD. Pharmacol Biochem Behav 90: 184-197, 2008.
Heal DJ and Pierce D. A review of methylphenidate and its isomers and their role in the treatment of attention deficit hyperactivity disorder. CNS Drugs 20: 713 738, 2006.
Posters
Jackson HC et al. Comparison of the effects of equivalent doses of lisdexamfetamine dimesylate and d-amphetamine on extracellular concentrations of striatal dopamine, locomotor activity and plasma d-amphetamine concentrations in freely-moving rats. Program No 775.23. Society for Neuroscience Meeting, Washington, DC, 12th-16th November 2011. Please contact us for a copy of the poster.
Rowley HL et al. Lisdexamfetamine dimesylate versus d-amphetamine - Hysteresis analyses of the relationships between extracellular striatal dopamine and locomotor activity measured in freely-moving rats. Program No 775.11. Society for Neuroscience Meeting, Washington, DC, 12th-16th November 2011. Please contact us for a copy of the poster.
Cheetham SC et al. Differences in presynaptic mechanisms of the ADHD drugs, d-amphetamine and methylphenidate, revealed by "neurochemical fingerprinting”: correlations between dopamine neurochemistry and behavioural function. Program No 669.21. Society for Neuroscience Meeting, San Diego, California, 13th-17th November 2010. View poster
Heal DJ et al. Further validation of “neurochemical fingerprinting” to characterise drugs with different presynaptic dopaminergic mechanisms: comparison with in vivo microdialysis. Program No. 669.22. Society for Neuroscience Meeting, San Diego, California, 13th-17th November 2010. View poster
Cheetham SC et al. Sequential determination of limbic and striatal behavioural function and dopamine neurochemistry in C57/BL6 mice. Program No. 843.16. Society for Neuroscience Meeting, Chicago, Illinois, 17th-21st October 2009. View poster
Heal DJ et al. “Neurochemical fingerprinting” as a rapid technique to discriminate between drugs with different presynaptic dopaminergic mechanisms. Program No. 421.2. Society for Neuroscience Meeting, Chicago, Illinois, 17th-21st October 2009. View poster
Viggers, JA et al. Development and validation of a radioligand receptor binding assay for MCH1 receptors using [3H]AMR-MCH-1 in vitro and ex vivo. Program No. 584.27. Society for Neuroscience Meeting, Washington, DC, 15th-19th November 2008. View poster
Heal DJ et al. Demonstration of the relationship between the in vivo dopamine efflux, behaviour and drug pharmacokinetics. Poster at College on the Problems of Drug Dependence Meeting, Washington, DC, 27th-28th October 2008. View poster
Cheetham SC et al. The SH rat model of ADHD has profoundly different catecholaminergic responses to amphetamine’s enantiomers compared with Sprague-Dawleys. Program No. 386.14 Society for Neuroscience Meeting, San Diego, California, 3rd-7th November 2007. View poster
Heal DJ et al. A comparison using in vivo microdialysis of the catecholamine profiles of dexamphetamine and methylphenidate in an animal model of ADHD. Program No 386.7. Society for Neuroscience Meeting, San Diego, California, 3rd-7th November 2007. View poster
Heal DJ et al. Characterisation of the catecholaminergic profiles of methyphenidate and its enantiomers in an animal model of ADHD by in vivo microdialysis. Program No. 97.4. Society for Neuroscience Meeting, Atlanta, Georgia, 14th-18th October 2006. View poster
Cheetham SC et al. Ex vivo occupancy as a technique to assess drug actions at multiple targets. Program No. 447.6. Society for Neuroscience Meeting, Washington, DC, 12th-16th November 2005. View poster
Rowley HL et al. Effects of HT-2157, a Galanin-3 receptor antagonist, on extracellular levels of 5-HT in various brain regions of freely-moving rats. Abstract No.167P. Proceedings of the BPS Winter meeting, London, December 2005. View poster
Rowley HL et al. The HT-2157 induced increase in extracellular 5-HT levels in the frontal cortex of freely-moving rats is modulated by 5 HT1A receptors. Abstract No.165P. Proceedings of the BPS Winter meeting, London, December 2005. View poster
