Most CNS drugs produce a pharmacologically specific interoceptive cue in rats that they can use to differentiate between the training drug and vehicle. Drug discrimination testing using abused drugs as the training cues is used to investigate whether novel CNS-active compounds produce similar psychoactive effects and is part of the regulatory Safety Pharmacology package. Test drugs that generalise to the comparator drug are likely to produce similar psychoactive effects in humans.
MDMA, PCP and cocaine:
A wide range of drug cues are available including:
All drug discrimination studies can be performed to GLP.
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