Early Assessment of Abuse Potential

RenaSci offers a battery of tests that can be used to explore the pharmacological profiles of novel drugs compared to known drugs of abuse. Allowing the early assessment of abuse potential.

 

Ex vivo binding to determine occupancy of the test drug at
abuse-related receptors, binding sites and transporters in the brain

Early Assessment of Abuse Potential Ex vivo binding to determine occupancy of the test drug at abuse-related receptors, binding sites and transporters in the brain

 

  • Intracerebral microdialysis to screen for abuse potential by investigating the effect of test compounds on extracellular dopamine in the nucleus accumbens or striatum
  • Neurochemical fingerprinting in mice to determine effects of drugs on presynaptic dopaminergic mechanisms compared to drugs of abuse

Head twitches in mice – a 5-HT2A  receptor-mediated behaviour to detect potential hallucinogens.

 

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