Intravenous self-administration in rats is an extremely reliable predictor of the risk of abuse by humans and this test forms an integral part of the Safety Pharmacology package that is part of the regulatory evaluation for all drugs that enter the brain.
Self-administration of heroin by rats on a FR-5 schedule of drug reinforcement
Reinforcing break-points of heroin, samidorphan, naltrexone and saline
All studies are designed and supervised by experts with substantial experience of interacting with the FDA and EMA.
Contact us for to discuss how intravenous self-administration studies can be used to assess the drug abuse liability of your compounds.
For more details or information on how we can support your project please complete the contact form.