We offer a wide range of behavioural and physiological assays that can be used to assess the mode of action, efficacy and side-effect profile of centrally acting drugs. They can also be used in proof-of-concept studies for novel molecular targets in the brain. These assays include:
Drugs (alone or in combination with a receptor agonist or antagonist) can be given by a variety of different routes (including intracerebroventricular injection). Blood and tissue samples can be collected for pharmacokinetic or neurochemical analysis or ex vivo binding if required.
Adding to our portfolio of CNS services, we have recently developed a model of Morphine- and Clonidine-induced mydriasis (see figures below).
These data demonstrate the temporal effects of these agents to dilate the pupils of conscious rats. This assay is being utilised to better understand the pharmacology of novel centrally acting drugs.
We work with clients to develop and validate novel behavioural and physiological functional assays.
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