We offer a wide range of behavioural and physiological assays that can be used to assess the mode of action, efficacy and side-effect profile of centrally acting drugs. They can also be used in proof-of-concept studies for novel molecular targets in the brain. These assays include:
Drugs (alone or in combination with a receptor agonist or antagonist) can be given by a variety of different routes (including intracerebroventricular injection). Blood and tissue samples can be collected for pharmacokinetic or neurochemical analysis or ex vivo binding if required.
Clonidine-induced mydriasis in mice:
A model of post-synaptic a2-adrenoceptor function
We work with clients to develop and validate novel behavioural and physiological functional assays.
For more details or information on how we can support your project please complete the contact form.