– Dopamine

Dopamine is a key neurotransmitter that is involved in both motor control and
reward-motivated behaviours. As such, the study of potentially addictive
drugs often involves the monitoring of dopamine levels within the brain.

 

The below data shows the effects of MDMA and PCP on dopamine in the
nucleus accumbens shell: a microdialysis experiment in freely‑moving rats

 

Results are adjusted means; n=5-6. SEMs are calculated from the residuals of the statistical model. Drug administration is indicated by the
vertical arrow and drug doses are for the free base. Data were log-transferred and analysed by ANCOVA with log (baseline) as a covariate.
Analysis was by separate Williams’ tests for comparisons of MDMA and PCP to vehicle. Significant differences versus vehicle: *p<0.05, **p<0.01, ***p<0.001.

 

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