Our rodent models of Type 2 diabetes (e.g. STZ-treated mice and rats on a high-fat diet or commercially available genetically diabetic animals) can be used to investigate the effects of drugs on serious microvascular complications of diabetes. These include diabetic nephropathy and diabetic neuropathy.
Our HFD STZ model can be used to assess potential treatments of diabetic nephropathy. We are able to determine the degree of renal impairment with a range of markers, these include:
Alongside our HFD STZ model, we can also assess kidney function in other models of nephropathy, for example, the ZDF rat.
Diabetic neuropathy can be assessed in animal models of diabetes by measuring:
We have shown the development of thermal hypoalgesia and mechanical allodynia in STZ-treated rodents maintained on a high-fat diet and db/db mice.
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