Genetic Models

RenaSci have extensive experience evaluating potential antidiabetic treatments in commercially available genetic animal models of insulin resistance or Type 2 diabetes. Animals genetically predisposed to developing syndromes with similar characteristics to insulin resistance or Type 2 diabetes in man include:

  •  ob/ob mice
  • db/db mice
  • Zucker fatty fa/fa rats
  • Zucker diabetic fatty fa/fa (ZDF) rats

 

These in-bred animal models develop spontaneous insulin resistance or overt diabetes due to a mutation in a single gene. All four models display obesity, hyperinsulinaemia and are insulin-resistant, but differ in the degree of hyperglycaemia.

 

Sitagliptin: Acute OGTT in ob/ob mice

Sitagliptin: Acute OGTT in ob/ob mice

 

Typical measurements in genetic models of insulin resistance and Type 2 diabetes include:

  • Glucose tolerance tests (iv, ip or po)
  • Blood HbA1c
  • Plasma biochemistry (e.g. fructosamine, cholesterol, HDL-C and LDL-C)
  • Urinary glucose excretion
  • Pancreatic insulin quantification

 

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