RenaSci have extensive experience evaluating potential antidiabetic treatments in commercially available genetic animal models of insulin resistance or Type 2 diabetes. Animals genetically predisposed to developing syndromes with similar characteristics to insulin resistance or Type 2 diabetes in man include:
These in-bred animal models develop spontaneous insulin resistance or overt diabetes due to a mutation in a single gene. All four models display obesity, hyperinsulinaemia and are insulin-resistant, but differ in the degree of hyperglycaemia.
Sitagliptin: Acute OGTT in ob/ob mice
Typical measurements in genetic models of insulin resistance and Type 2 diabetes include:
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