Naturalistic models of insulin resistance are based on the syndrome that accompanies dietary-induced obesity in normal, lean non-diabetic mice and rats fed a high-fat diet (HFD). This is much closer to the clinical situation, as dietary-induced obesity is a major predisposing risk factor for Type 2 diabetes in humans.
Dietary-induced obese (DIO) animals have moderate elevations in plasma insulin compared to control animals fed normal rodent chow. Both plasma glucose and insulin are increased following a glucose challenge, i.e. the obesity is associated with impaired glucose tolerance and insulin resistance.
Insulin resistance in dietary-induced obese animals
DIO mice and rats can be used to evaluate the effects of novel therapies on glycaemic control, hyperlipidaemia, hypertension and body weight.
Get in touch to find out more.
For more details or information on how we can support your project please complete the contact form.