Dietary-Induced Obesity and Insulin Resistance

Naturalistic models of insulin resistance are based on the syndrome that accompanies dietary-induced obesity in normal, lean non-diabetic mice and rats fed a high-fat diet (HFD). This is much closer to the clinical situation, as dietary-induced obesity is a major predisposing risk factor for Type 2 diabetes in humans.

Dietary-induced obese (DIO) animals have elevated basal levels of insulin and exhibit a marked insulin response and a prolonged plasma glucose excursion after a glucose load when compared to control animals fed normal rodent chow.

 

Insulin resistance in dietary-induced obese animals

 

Insulin resistance in dietary-induced obese animals

Insulin resistance in dietary-induced obese animals

n=10. Significant differences against vehicle by *p<0.05, ***p<0.001.

 

DIO mice and rats can be used to evaluate the effects of novel therapies on glycaemic control, hyperlipidaemia, hypertension and body weight.

 

Effect of Semaglutide on glucose tolerance in dietary-induced obese mice

glucose tolerance in dietary-induced obese mice

n=10. Significant differences against vehicle are denoted by *p<0.05, ***p<0.001.

 

 

Effect of Semaglutide on body weight in dietary-induced obese mice

 

body weight in dietary-induced obese mice

n = 10. Significant differences against vehicle are denoted by ***p<0.001. Arrows indicate dosing days.

 

 

Effect of Semaglutide on cumulative daily food intake in dietary-induced obese mice

 

n = 10. Significant differences against vehicle are denoted by ***p<0.001.

 

 

Effect of Semaglutide on body composition (DEXA scan) in dietary-induced obese mice

 

body composition (DEXA scan) in dietary-induced obese mice

n=10. Significant differences against vehicle are denoted by **p<0.01, ***p<0.001.

 

 

Effect of Semaglutide on liver lipids in dietary-induced obese mice

 

liver lipids in dietary-induced obese mice

n=10. Significant differences against vehicle are denoted by *p<0.05, ***p<0.001.

 

 

 

Effect of Semaglutide on the plasma parameters in dietary-induced obese mice

 

plasma parameters in dietary-induced obese mice

n=10. Significant differences against vehicle are denoted by ***p<0.001.

 

 

 

 

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