Dietary-Induced Obesity and Insulin Resistance

Naturalistic models of insulin resistance are based on the syndrome that accompanies dietary-induced obesity in normal, lean non-diabetic mice and rats fed a high-fat diet (HFD). This is much closer to the clinical situation, as dietary-induced obesity is a major predisposing risk factor for Type 2 diabetes in humans.

Dietary-induced obese (DIO) animals have moderate elevations in plasma insulin compared to control animals fed normal rodent chow. Both plasma glucose and insulin are increased following a glucose challenge, i.e. the obesity is associated with impaired glucose tolerance and insulin resistance.

 

Insulin resistance in dietary-induced obese animals

Insulin resistance in dietary-induced obese animals

 

DIO mice and rats can be used to evaluate the effects of novel therapies on glycaemic control, hyperlipidaemia, hypertension and body weight.

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