Our perifused pancreatic islet system can be used to determine whether potential antidiabetic agents alter insulin secretion from ß-cells in vitro. The islet assay established and validated by RenaSci can, therefore, be used as an invaluable tool in early screening for Type 2 diabetes drug discovery programmes.

Key features of the assay include:

• Direct measurement of perifused pancreatic islet insulin secretion in vitro
• Detailed mechanistic studies
• Medium-throughput screening

 

Glucose-stimulated insulin secretion from
perifused pancreatic islets

 

GLP-1 increases glucose-stimulated insulin
secretion from perifused pancreatic islets

Get in touch to learn more about RenaSci’s in vitro pancreatic islet assay.