DMPK

Renasci’s team of experts can offer a comprehensive DMPK package in partnership with our parent company, the Sygnature discovery group. There is also the option of working in combination with your preferred analytical provider. Additionally we can produce tailor made DMPK studies with fast turnaround times.

Click here to find out more about what can be analysed as a package.

 

We have the following routes available in both, rat and mouse models:

  • Oral
  • Intravenous
  • Subcutaneous
  • Intraperitoneal
  • Intratracheal
  • Intranasal
  • ICV (mouse single dose only using stereotaxic apparatus)
  • Implanted venous/arterial cannula (single/dual)
  • Oropharyngeal (rat/mouse) Coming soon…
  • Intravitreal (rat) Coming soon…
  • Microdialysis (rat/mouse) Coming soon…

 

Additionally, route combinations (including cassette dosing) are available for more complex studies.

 

IV: Study 1 Vs Study 2

IV DMPK

IV DMPK

 

 

 

PO: Study 1 Vs Study 2

 

PO DMPK

 

These results demonstrate the reproducibility of data points across two separate studies using the same test substance. This simple single dose, repeat sampling model gives quick assessment of compound availability for your project.

Alternatively, using cassette dosing, this model can be used as a cost effective screen to test multiple substances in a single dose thereby reducing the number of animals used in accordance with the 3R’s and reducing screening costs.

 

 

These graphs compare: Nebivolol 1.0 mg/kg IV Blood and Nebivolol 2.0 mg/kg PO Blood

 

 

Get in touch to find out more.

 

Contact us

For more details or information on how we can support your project please complete the contact form.