Our preclinical rodent models of kidney disease provide a fully-validated platform to determine the utility of novel test compounds for the treatment of kidney diseases.

We pride ourselves on a collaborative approach to new model development, so if there is a new assay or model of renal disease that you are interested in, please don’t hesitate to contact us.

 

Rodent models of Chronic Kidney Disease

• Adriamycin-induced mouse model of focal segmental glomerulosclerosis (FSGS)
• Antibody-induced anti-GBM Disease mouse and rat model of glomerulonephritis (GN)
• Unilateral Ureteral Obstruction (UUO) mouse and rat model of fibrosis – coming soon..

 

Rodent models of Diabetic Kidney Disease

• Streptozotocin (STZ)-treated high fat diet (HFD)-fed mouse and rat models of diabetic kidney disease. See also the RenaSci Streptozotocin/High-Fat Diet Model of Type 2 Diabetes
• Genetic models of type 2 diabetes (e.g. db/db, ZDF). See also the RenaSci Genetic Models of Insulin Resistance and Type 2 Diabetes
• Uninephrectomised db/db mouse model – coming soon…
• Diet-induced obese (DIO) mouse model of kidney damage – coming soon…

 

Clinical Biomarkers- see here

• Plasma parameters
• Urinary parameters
• Kidney histopathology

 

Precision Cut Kidney Slices 

• Ex Vivo model of renal fibrosis coming soon…

 

Get in touch to find out more.