Focal segmental glomerulosclerosis (FSGS) in rodents, one of the most common causes of primary glomerular diseases in adults is induced by Adriamycin (anthracycline also called Doxorubicin). Renasci developed the adriamycin-induced nephropathy model; FSGS where structural and functional injury mimics chronic proteinuric kidney disease in human.
The model is characterised by:
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