Focal segmental glomerulosclerosis (FSGS) in rodents, one of the most common causes of primary glomerular diseases in adults is induced by Adriamycin (anthracycline also called Doxorubicin).  Renasci developed the adriamycin-induced nephropathy model; FSGS where structural and functional injury mimics chronic proteinuric kidney disease in human.

The model is characterised by:

• Quick induction of renal injury, it occurs within days of Adriamycin administration
• Customisable study design tailored to determine prevention or reversal of phenotype
• Prevention and partial reversal of the phenotype has been demonstrated using Enalapril

 

Statistical differences: ***p<0.001 vs Vehicle; † † p<0.01 vs STZ

 

 

• Fibrotic phenotype that could be prevented with inhibition of TGFβ receptor I

 

 

Statistical differences: *p<0.5, **p<0.01 vs ADR

 

 

 

 

 

 

 

 

 

 

 

 

 

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