Adriamycin-induced Nephropathy

Focal segmental glomerulosclerosis (FSGS) in rodents, one of the most common causes of primary glomerular diseases in adults is induced by Adriamycin (anthracycline also called Doxorubicin).  Renasci developed the adriamycin-induced nephropathy model; FSGS where structural and functional injury mimics chronic proteinuric kidney disease in human.

The model is characterised by:

  • Quick induction of renal injury, it occurs within days of Adriamycin administration
  • Customisable study design tailored to determine prevention or reversal of phenotype
  • Prevention and partial reversal of the phenotype has been demonstrated using Enalapril

 

Adriamycin-induced Nephropathy model

Adriamycin-induced Nephropathy model

Statistical differences: ***p<0.001 vs Vehicle; † † p<0.01 vs STZ

 

 

  • Fibrotic phenotype that could be prevented with inhibition of TGFβ receptor I

 

Adriamycin-induced Nephropathy model

 

Statistical differences: *p<0.5, **p<0.01 vs ADR

Kidney histology

 

 

 

 

 

 

 

 

 

 

 

 

 

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