Antibody-induced anti-GBM Disease

 

Glomerulonephritis is a group of diseases involving damage to the glomeruli caused by inflammation. RenaSci developed  the Antibody-induced anti-GBM Disease Models model of glomerulonephritis that is induced by immunization with collagen type IV antibodies.

 

Anti-GBM model is characterised  by:

  • Rapid onset of inflammatory cell infiltration
  • Severe proteinuria
  • Plasticity: Enalapril, Empagliflozin and Dexamethasone are effective in rescuing kidney phenotype in this model

Antibody-induced anti-GBM Disease

Antibody-induced anti-GBM Disease

Statistical differences: *p<0.05 **p<0.01 ***p<0.001 vs Vehicle; † p<0.5, † † p<0.01 vs anti-GBM

 

  • The anti-GBM model develops a mild fibrotic phenotype where tubulointerstitial fibrosis can be prevented with Dexamethasone

 

Kidney histology

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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