Kidney Function and Pathology

RenaSci provides a range of assays for evaluating kidney function and pathology in mice or rats. Analysis can be performed on samples from our own models of renal disease or on urine, plasma or kidney samples from external studies.

 

The effects of drugs on the following parameters can be measured during studies:

  • Urine volume (collected in specific metabolic cages)
  • Water intake
  • Urine albumin, protein and creatinine and other biomarkers of kidney function
  • Urine albumin creatinine ratio (uACR) and urine protein creatinine ratio (uPCR)
  • Glomerular filtration rate (FITC inulin clearance test)
  • Plasma creatinine and urea
  • Creatinine clearance estimation

 

At the end of studies, kidneys can be weighed and processed for histological assessment by a pathologist (PathCelerate) using light microscopy.
The following parameters can be scored:

  • Tubular protein
  • Tubular degeneration/regeneration
  • Tubulo-interstitial inflammation
  • Glomerulosclerosis
  • Interstitial Fibrosis
  • Glomerular Fibrosis

 

 

Get in touch for further details of our techniques for assessing renal function and kidney disease.

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