Experimental model of diabetes is induced in rodents by administration of streptozotocin (STZ), a glucosamine–nitrosourea compound that damages pancreatic β cells, resulting in hyperglycaemia. RenaSci have developed mouse and rat models of STZ/HFD Model of Type 2 Diabetes where animals administered STZ are fed a high fat diet.

The STZ/HFD Model of Type 2 Diabetes model is characterised by:

• Impaired glucose tolerance when fed a high fat diet
• Similar development of chronic kidney injury in mice and rats
• Stable phenotype (compound dosing for up to 140 days)
• Plasticity: we showed that an endothelin-converting enzyme/neutral endopeptidase inhibitor is effective in preventing the injury
• Fully customisable study design

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