RenaSci’s H-FFC mouse develops a robust NASH and fibrosis phenotype within a 12 week period. Utilizing a high-fat, high-fructose, high-cholesterol (H-FFC) diet the overweight H-FFC mouse has advantages over the traditional MCD and CD dietary models, both of which induce weight loss. The RenaSci H-FFC mouse model is therefore more akin to the clinical presentation of the disease.
The mice in the model are maintained on a H-FFC diet for 12 weeks, this results in an increase in the following parameters:
The dual PPAR alpha /delta agonist, elafibranor reduces or inhibits many of the features of NASH and fibrosis in RenaSci’s H-FFC mouse. This demonstrates its usefulness as a model to identify potential treatments of NASH and fibrosis.
RenaSci’s H-FFC mouse had significantly (p <0.05) increased body weight compared to the standard chow vehicle from Day 2, except for on Days 6-14 and 17. Elafibranor significantly (p <0.001) reduced body weight versus standard chow vehicles from Day 3 and versus the H-FFC vehicle group from Day 2. Elafibranor decreased body weight by 20% compared to the standard diet vehicles and 29% compared to the H-FFC vehicle controls.
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