Acute Feeding Studies

Acute feeding studies are one of the simplest screens for measuring the anti-obesity potential of a novel drug in both rat and mouse models.  Following acute administration, the drug’s effects on food intake is evaluated.

Key features in these studies are:

  • Male lean rats or mice (singly housed)
  • Drugs administered by various routes, eg po, sc, ip
  • Mice acclimatised to palatable wet mash (4 h/day). Drugs given 60 min before mash. Food intake normally measured over 1, 2 and 4 h
  • Rats maintained under reverse-phase lighting with free access to normal, powdered rat chow. Drugs given at onset of dark period. Food intake normally measured for up to 24 h
  • Determination of ED50 values for inhibition of food intake
  • Blood sampling for pharmacokinetic analysis (at the end of studies or from satellite groups of animals)

 

Acute feeding studies in mice:

 

 

Effect of acute PYY3-36 on mash consumption

Effect of PYY

 

 

Effect of Rimonabant on mash consumption

Effect of Rimonabant

 

 

Effect of Sibutramine on mean mash consumption

effect of sibutramine

 

 

 

Acute feeding studies in rats:

 

effect of sibutramine

The studies can be extended by giving drugs repeatedly for up to 7 days if a delayed onset of action is suspected.

Get in touch to find out more.

 

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