Chronic feeding studies are required to evaluate the effects of novel anti-obesity drugs on bodyweight and the intake of food and water.
Chronic feeding studies can be performed in normal, lean rats or mice, or in animal models of obesity. Drugs can be given by a variety of routes (including sustained infusion via sc implanted osmotic minipumps or programmable, refillable micro-infusion iPRECIO® pumps).
Bodyweight and intake of food are measured routinely in chronic feeding studies.
Other endpoints in chronic feeding studies include:
Effect of rimonabant or change of diet on body weight in DIO mice
Effect of rimonabant or change of diet on daily food intake in DIO mice
Effect of rimonabant or change of diet on plasma glucose and insulin
levels in DIO mice: day 28 OGTT
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