Drug-induced Weight Gain

A common side-effect of certain antidiabetic drugs, for example, pioglitazone, is weight gain. This is a serious disadvantage in the clinic, as many diabetic patients are overweight or obese, and further weight gain is undesirable. Animal models can be used to explore the potential of novel antidiabetic drugs to produce weight gain in man. Pioglitazone increases body weight in dietary-induced obese rats.

Drug-induced weight-gain is also a serious side-effect of certain atypical (second generation) antipsychotic drugs such as olanzapine. We therefore developed an animal model of antipsychotic-induced weight gain (neuroleptic-induced weight gain) that can be used to investigate the effects of novel antipsychotic drugs on body weight. (link to appropriate page in CNS section).

These animal models can also be used to explore whether novel antiobesity agents can prevent the increase in body weight produced by other drug treatments.

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