High Fat Fed Rats

Feeding studies can be performed in normal, outbred rats maintained on a high fat diet for two weeks prior to the study. Male rats are normally used for this assay. The animals are in an active growth phase and rapidly gain weight on the high fat diet, but are not obese. The high fat-fed ‘overweight’ rat model is an excellent polygenic screen for investigating the efficacy and tolerability of drugs before chronic feeding studies in dietary-induced obese rats. The high fat-fed rat model does not include a lengthy induction of obesity period, and therefore animals are readily available.

 

Effect of the 5-HT6 receptor antagonist, AMR-SIX-1,
on body weight in high fat fed rats

Effect of the 5-HT6 receptor antagonist, AMR-SIS-1, on body weight in high fat fed rats

 

Effect of the 5-HT6 receptor antagonist, AMR-SIX-1,
on food intake in high fat fed rats

Effect of the 5-HT6 receptor antagonist, AMR-SIX-1, on food intake in high fat fed rats

 

Studies in our high fat fed ‘overweight’ rat model can include blood and tissue sampling and measurement of a variety of different parameters.

Please contact us for more information on the high fat-fed ‘overweight’ rat model.

Contact us

For more details or information on how we can support your project please complete the contact form.