High Fat Fed Rats

High fat fed rat feeding studies can be performed in normal, outbred rats that are maintained on a high fat diet for two weeks prior to the study. Male rats are normally used for this assay. The animals are in an active growth phase and rapidly gain weight on the high fat diet, but are not obese. The high fat-fed ‘overweight’ rat model is an excellent polygenic screen for investigating the efficacy and tolerability of drugs before chronic feeding studies in dietary-induced obese rats. The high fat-fed rat model does not include a lengthy induction of obesity period, and therefore animals are readily available.

 

Effect of chronic administration of sibutramine  and rimonabant on
body weight in male Sprague-Dawley rats maintained on a high fat diet
expressed as change in body weight per week.

ffect of chronic administration of sibutramine and rimonabant on body weight in male Sprague-Dawley rats maintained on a high fat diet expressed as change in body weight per week.

Data are adjusted means. SEMs are calculated from residuals of the statistical model; n=9-10.
Drug doses are for the free base. Data analysed by ANCOVA with Day 1 as covariate.
Significant difference from vehicle assessed using a t test: *p<0.05, **p<0.01, ***p<0.001.

 

 

Effect of chronic administration of sibutramine  and rimonabant on
food intake in male Sprague-Dawley rats maintained on a high fat diet
expressed as average daily food intake per week. 

Effect of chronic administration of sibutramine and rimonabant on body weight in male Sprague-Dawley rats maintained on a high fat diet.

Data are adjusted means. SEMs are calculated from residuals of the statistical model; n=9-10.
Drug doses are for the free base. Data analysed by ANCOVA with average of Days -6 to 0 as covariate.
Significant difference from vehicle assessed using Dunnett’s test:   *p<0.05, ***p<0.001.

 

 

 

Effect of chronic administration of sibutramine  and rimonabant on body weight
in male Sprague-Dawley rats maintained on a high fat diet.

 Effect of chronic administration of sibutramine and rimonabant on body weight in male Sprague-Dawley rats maintained on a high fat diet.

Data are adjusted means. SEMs are calculated from residuals of the statistical model; n=9-10.
Drug doses are for the free base. Drug treatment commenced on Day 1. Data analysed by ANCOVA with Day 1 as covariate.
Significant difference from vehicle assessed using a t test: *p<0.05, **p<0.01, ***p<0.001.

 

 

 

Effect of chronic administration of sibutramine and rimonabant on food intake
in male Sprague-Dawley rats maintained on a high fat diet.

 

Effect of chronic administration of sibutramine and rimonabant on food intake in male Sprague-Dawley rats maintained on a high fat diet.

Data are simple means ± sem; n=8-10. Drug doses are for the free base. Drug treatment commenced on Day 1.
Data  analysed by ANOVA. Significant difference from vehicle assessed using Dunnett’s test: *p<0.05, ** p < 0.01, ***p<0.001.

 

Studies in our high fat fed ‘overweight’ rat model can include blood and tissue sampling and measurement of a variety of different parameters.

Please contact us for more information on the high fat-fed rats model.

Contact us

For more details or information on how we can support your project please complete the contact form.