Pair-feeding studies in animals explore the contribution made by reduced food intake to drug-induced reductions in bodyweight. In pair-feeding studies, the amount of food eaten by the drug treatment group each day is determined, and given to a vehicle-treated ‘pair-fed’ group of animals housed under identical conditions the following day. If the weight-loss in the pair-fed animals is the same as the drug-treatment group, the drug is likely to be reducing body weight by inhibiting food intake. Drugs reducing food intake and also increasing energy output would be expected to produce greater weight-loss than the corresponding pair-fed group.
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