Publications

Experimental

  • All

Type

  • All

Elafibranor and pioglitazone reduce NASH and fibrosis in a genetically-obese dietary induced NASH mouse model

Katie R. Headland, Katie Dickinson, Sharon C Cheetham

Find out more
nash
posters

Animal models of non-alcoholic steatohepatitis: comparison of the MCD, CD, H-FFC and ob/ob H-FFC mouse

Katie R Headland, Sheila H DeWitt, Vincent Jacques, Steven Vickers, Sharon Cheetham

Find out more
nash
posters

An investigation of the reinforcing potential of PN6047 by conditioned place preference testing in rats

J. Palandri, C Bailey, D.J. Heal, D. Kendall

Find out more
abuse-dependence
posters

Investigation of the reinforcing potential of samidorphan and naltrexone by fixed and progressive ratio intravenous self-administration testing in heroin-maintained rats

Smith SL, Dean RL, Todtenkopf MS, Heal DJ

Find out more
abuse-dependence, cns
journal-papers

Which drug is the most reinforcing? Comparison of heroin, cocaine, MDMA and nicotine by intravenous self-administration

S. Smith, M. Burnett, M. Hallam, S. Holland, Z. Turnbull, J. Slade, D. Heal

Find out more
abuse-dependence, cns
posters

Progressive Ratio (PR) Intravenous Self-Administration Testing in Rats to Assess the Relative Reinforcing Effects of a Wide Range of Substances of Abuse

SL Smith, SJ Holland, J Slade, M Hallam and DJ Heal

Find out more
abuse-dependence, cns
posters

Use of In Vivo Intracerebral Microdialysis in Rats to Identify Stimulant Drugs of Abuse

Heal DJ, Kulkarni RS, Pinder L and Rowley HL

Find out more
abuse-dependence, cns
posters

Determination of the relative reinforcing effect of MDMA by fixed ratio (FR) and progressive ratio (PR) intravenous self administration testing in rats

SL Smith, M. Hallam and DJ Heal

Find out more
abuse-dependence
posters

An investigation of the discriminative stimulus and reinforcing effects of cannabidiol in rats

Heal DJ, Smith SL, Gosden J, Holland S, Gray RA

Find out more
abuse-dependence
posters

Evaluating the abuse potential of psychedelic drugs as part of the safety pharmacology assessment for medical use in humans

David J Heal, Jane Gosden, Sharon L Smith

Find out more
abuse-dependence, cns
journal-papers

Intravenous self-administration evaluation of the possible reinforcing effects of Blue-181 compared with butorphanol and heroin

S. Smith, M. Hallam, Z. Turnbull, D. Roberson, M. Painter, A. Yekkirala, D. Heal

Find out more
abuse-dependence, cns
posters

Investigation of the effects of dasotraline in a validated rat model of binge-eating disorder

David J Heal, Steven P Vickers, Seth C Hopkins and Kenneth S Koblan

Find out more
cns
posters

Psychedelics – Re-opening the doors of perception

Heal DJ, Henningfield J, Frenguelli BG, Nutt DJ, Smith SL

Find out more
abuse-dependence
journal-papers

Inhibition of alpha7 nicotinic receptors in the ventral hippocampus selectively attenuates reinstatement of morphine-conditioned place preference and associated changes in AMPA receptor binding

Wright VL, Georgiou P, Bailey A, Heal DJ, Bailey CP, Wonnacott S

Find out more
cns
journal-papers

Investigation of impulsivity in binge-eating rats in a delay-discounting task and its prevention by the d-amphetamine prodrug, lisdexamfetamine

Steven P Vickers, Simon Goddard, Richard J Brammer, Peter H Hutson and David J Heal

Find out more
abuse-dependence, cns
journal-papers

Evaluation Of Elafibranor In The Choline-Deficient Diet Mouse Model Of NASH

Sharon C Cheetham, Katie R Headland, Mike R Prow, Lucy A Pinder, Robert B Jones & Steven P Vickers

Find out more
nash
posters

Dopamine and μ-opioid receptor dysregulation in the brains of binge-eating female rats – possible relevance in the psychopathology and treatment of binge-eating disorder

David J Heal, Michelle Hallam, Michael Prow, Jane Gosden, Sharon Cheetham, Yong K Choi, Frank Tarazi and Peter Hutson

Find out more
abuse-dependence, cns
journal-papers

The MetAP2 Inhibitor ZGN-1061 Improves Glycaemia in High-Fat Diet-Induced Obese Mice

Bryan F. Burkey, James E. Vath, Margaret Wyman, Steven Vickers, Sharon Cheetham, Keith Dickinson, Gareth Birmingham, Thomas E. Hughes

Find out more
obesity
Posters

Histologic Characterization of Retina Neuroglia Modifications in Diabetic Zucker Diabetic Fatty Rats

Fernandez-Bueno I, Jones R, Soriano-Romaní L, López-García A, Galvin O, Cheetham S, Diebold Y

Find out more
diabetes
journal-papers

The NK1R-/- mouse phenotype suggests that small body size, with a sex- and diet-dependent excess in body mass and fat, are physical biomarkers for a human endophenotype with vulnerability to attention deficit hyperactivity disorder

Pillidge K, Heal DJ, Stanford SC

Find out more
abuse-dependence, obesity
journal-papers

Lisdexamfetamine reduces the compulsive and perseverative behaviour of binge-eating rats in a novel food reward/punished responding conflict model

Heal DJ, Goddard S, Brammer RJ, Hutson PH, Vickers SP

Find out more
abuse-dependence
journal-papers

The effects in rats of lisdexamfetamine in combination with olanzapine on mesocorticolimbic dopamine efflux, striatal dopamine D2 receptor occupancy and stimulus generalization to a D-amphetamine cue

Hutson PH, Rowley HL, Gosden J, Kulkarni RS, Slater N, Love PL, Wang Y, Heal D

Find out more
abuse-dependence
journal-papers

A sustained release formulation of novel quininib-hyaluronan microneedles inhibits angiogenesis and retinal vascular permeability in vivo

Galvin O, Srivastava A, Carroll O, Kulkarni R, Dykes S, Vickers S, Dickinson K, Reynolds AL, Kilty C, Redmond G, Jones R, Cheetham S, Pandit A, Kennedy BN

Find out more
diabetes
journal-papers

Effects of lisdexamfetamine in a rat model of binge-eating

Vickers SP, Hackett D, Murray F, Hutson PH, Heal DJ

Find out more
abuse-dependence
journal-papers

New Drug Design and Therapeutic Development for Weight Reduction: Preclinical Studies and Clinical Trials

Steven P. Vickers, Helen C. Jackson and Sharon C. Cheetham

Find out more
obesity
journal-papers

Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments

Byrne FM, Cheetham S, Vickers S, Chapman V

Find out more
diabetes
journal-papers

Atomoxetine reduces hyperactive/impulsive behaviours in neurokinin-1 receptor ‘knockout’ mice

Pillidge K, Porter AJ, Vasili T, Heal DJ, Stanford SC

Find out more
abuse-dependence
journal-papers

The behavioural response of mice lacking NK₁ receptors to guanfacine resembles its clinical profile in treatment of ADHD

Pillidge K, Porter AJ, Dudley JA, Tsai YC, Heal DJ, Stanford SC

Find out more
abuse-dependence
journal-papers

Antidiabetic effects of the Cimicifuga racemosa extract Ze 450 in vitro and in vivo in ob/ob mice

Moser C, Vickers SP, Brammer R, Cheetham SC, Drewe J

Find out more
diabetes
journal-papers

Dopamine reuptake transporter (DAT) “inverse agonism” – a novel hypothesis to explain the enigmatic pharmacology of cocaine

Heal DJ, Gosden J, Smith SL

Find out more
abuse-dependence, cns
journal-papers

Combination of the sodium-glucose cotransporter-2 inhibitor empagliflozin with orlistat or sibutramine further improves the body-weight reduction and glucose homeostasis of obese rats fed a cafeteria diet

Vickers SP, Cheetham SC, Headland KR, Dickinson K, Grempler R, Mayoux E, Mark M, Klein T

Find out more
obesity, diabetes
journal-papers

Contrasting changes in extracellular dopamine and glutamate along the rostrocaudal axis of the anterior cingulate cortex of the rat following an acute d-amphetamine or dopamine challenge

Ash ES, Heal DJ, Clare Stanford S

Find out more
abuse-dependence, cns
journal-papers

Effect of linagliptin, alone and in combination with voglibose or exendin-4, on glucose control in male ZDF rats

Jones RB, Vickers SP, Cheetham SC, Headland KR, Mark M, Klein T

Find out more
diabetes
journal-papers

Evidence-based guidelines for the pharmacological management of attention deficit hyperactivity disorder: update on recommendations from the British Association for Psychopharmacology

Bolea-Alamañac B, Nutt DJ, Adamou M, Asherson P, Bazire S, Coghill D, Heal D, Müller U, Nash J, Santosh P, Sayal K, Sonuga-Barke E, Young SJ

Find out more
abuse-dependence
journal-papers

Differences in the neurochemical and behavioural profiles of lisdexamfetamine methylphenidate and modafinil revealed by simultaneous dual-probe microdialysis and locomotor activity measurements in freely-moving rats

Rowley HL, Kulkarni RS, Gosden J, Brammer RJ, Hackett D, Heal DJ

Find out more
abuse-dependence, cns
journal-papers

A preclinical evaluation of the discriminative and reinforcing properties of lisdexamfetamine in comparison to D-amfetamine, methylphenidate and modafinil

Heal DJ, Buckley NW, Gosden J, Slater N, France CP, Hackett D

Find out more
abuse-dependence, cns
journal-papers

Amphetamine, past and present – a pharmacological and clinical perspective

Heal DJ, Smith SL, Gosden J, Nutt DJ

Find out more
abuse-dependence
journal-papers

Pharmacological differences between rat frontal cortex and hippocampus in the nicotinic modulation of noradrenaline release implicate distinct receptor subtypes

Kennett A, Heal DJ, Wonnacott S

Find out more
cns
Journal Papers

Evaluation of body fat composition after linagliptin treatment in a rat model of diet-induced obesity: a magnetic resonance spectroscopy study in comparison with sibutramine

Klein T, Niessen HG, Ittrich C, Mayoux E, Mueller HP, Cheetham S, Stiller D, Kassubek J, Mark M

Find out more
obesity, diabetes
journal-papers

Metabolic consequences of antipsychotic therapy: preclinical and clinical perspectives on diabetes, diabetic ketoacidosis, and obesity

Heal DJ, Gosden J, Jackson HC, Cheetham SC, Smith SL

Find out more
cns, obesity, diabetes
journal-papers

Lisdexamfetamine and immediate release d-amfetamine – differences in pharmacokinetic/pharmacodynamic relationships revealed by striatal microdialysis in freely-moving rats with simultaneous determination of plasma drug concentrations and locomotor activity

Rowley HL, Kulkarni R, Gosden J, Brammer R, Hackett D, Heal DJ

Find out more
abuse-dependence
journal-papers

Effects of saxagliptin and sitagliptin on glycaemic control and pancreatic β-cell mass in a streptozotocin-induced mouse model of type 2 diabetes

Poucher SM, Cheetham S, Francis J, Zinker B, Kirby M, Vickers SP

Find out more
diabetes
journal-papers

Effects of the DPP-4 inhibitor, linagliptin, in diet-induced obese rats: a comparison in naive and exenatide-treated animals

Vickers SP, Cheetham SC, Birmingham GD, Rowley HL, Headland KR, Dickinson K, Grempler R, Hocher B, Mark M, Klein T

Find out more
obesity
journal-papers

ADHD: current and future therapeutics

Heal DJ, Smith SL, Findling RL

Find out more
abuse-dependence, cns
journal-papers

Animal models to explore the effects of CNS drugs on food intake and energy expenditure

Vickers SP, Clifton PG

Find out more
cns, obesity
journal-papers

A review of late-stage CNS drug candidates for the treatment of obesity

Heal DJ, Gosden J, Smith SL

Find out more
cns, obesity
journal-papers

What is the prognosis for new centrally-acting anti-obesity drugs?

Heal DJ, Gosden J, Smith SL

Find out more
cns, obesity, diabetes
journal-papers

Some cannabinoid receptor ligands and their distomers are direct-acting openers of SUR1 K(ATP) channels

Lynch CJ, Zhou Q, Shyng SL, Heal DJ, Cheetham SC, Dickinson K, Gregory P, Firnges M, Nordheim U, Goshorn S, Reiche D, Turski L, Antel J

Find out more
diabetes
journal-papers

The 5-HT6 receptor as a target for developing novel antiobesity drugs

Heal D, Gosden J, Smith S

Find out more
obesity
journal-papers

The utility of animal models to evaluate novel anti-obesity agents

Vickers SP, Jackson HC, Cheetham SC

Find out more
obesity
journal-papers

Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake

Gardiner JV, Bataveljic A, Patel NA, Bewick GA, Roy D, Campbell D, Greenwood HC, Murphy KG, Hameed S, Jethwa PH, Ebling FJ, Vickers SP, Cheetham S, Ghatei MA, Bloom SR, Dhillo WS

Find out more
obesity
journal-papers

Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders

Heal DJ, Gosden J, Smith SL

Find out more
obesity, diabetes
journal-papers

The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safety

Heal DJ, Cheetham SC, Smith SL

Find out more
cns
journal-papers

Receptor occupancy and brain free fraction

Watson J, Wright S, Lucas A, Clarke KL, Viggers J, Cheetham S, Jeffrey P, Porter R, Read KD

Find out more
cns
journal-papers

New perspectives from microdialysis studies in freely-moving, spontaneously hypertensive rats on the pharmacology of drugs for the treatment of ADHD

Heal DJ, Smith SL, Kulkarni RS, Rowley HL

Find out more
cns
journal-papers

Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders

Heal DJ, Smith SL, Fisas A, Codony X, Buschmann H

Find out more
obesity
journal-papers

GPR39 signaling is stimulated by zinc ions but not by obestatin

Holst B, Egerod KL, Schild E, Vickers SP, Cheetham S, Gerlach LO, Storjohann L, Stidsen CE, Jones R, Beck-Sickinger AG, Schwartz TW

Find out more
obesity
journal-papers

Methylphenidate and its isomers: their role in the treatment of attention-deficit hyperactivity disorder using a transdermal delivery system

Heal DJ, Pierce DM

Find out more
cns
journal-papers

Contact us

For more details or information on how we can support your project please complete the contact form.