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Determination of the relative reinforcing effect of MDMA by fixed ratio (FR) and progressive ratio (PR) intravenous self administration testing in rats

2018 SfN Smith et al. MDMA IVSA

There is resurgent interest in developing psychedelic drugs, eg 5-HT2A agonists, NMDA antagonists and κ-opioid agonists, to treat serious psychiatric and neurological disorders. For example, the FDA recently granted breakthrough status to the schedule 1 controlled drug, MDMA, for the treatment of post-traumatic stress disorder (PTSD). The abuse potential of most psychedelic drugs has not been systematically investigated, and furthermore, all novel psychedelic compounds developed as drugs for human use need to have their reinforcing potential determined as part of the CNS Safety Pharmacology package. Since there are relatively few published studies describing the reinforcing effects of MDMA in rats, we investigated whether MDMA served as positive reinforcer in  heroin-maintained rats and its relative reinforcing effect.



Determination of the relative reinforcing effect of MDMA by fixed ratio (FR) and progressive ratio (PR) intravenous self administration testing in rats

Experimental

Abuse & Dependence

Author

SL Smith, M. Hallam and DJ Heal

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