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An investigation of the reinforcing potential of PN6047 by conditioned place preference testing in rats

PN6047, which is a novel, selective δ-opioid agonist, is being developed to treat persistent chronic pain. PN6047’s reinforcing potential has been evaluated in conditioned place preference (CPP) using rats as the experimental subjects. Heroin was used as the positive control and hydroxy-propyl-methylcellulose (HPMC) vehicle as the negative control.

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An investigation of the reinforcing potential of PN6047 by conditioned place preference testing in rats

Experimental

Abuse & Dependence

Author

J. Palandri, C Bailey, D.J. Heal, D. Kendall