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Animal models of non-alcoholic steatohepatitis: comparison of the MCD, CD, H-FFC and ob/ob H-FFC mouse

Many animal models of non-alcoholic steatohepatitis (NASH) have been developed which mirror various aspects of the disease and choosing the most appropriate is a key question faced by the pharmaceutical industry. The aim of this present study was to characterise RenaSci’s four dietary-induced NASH mouse models, specifically the methionine/choline deficient (MCD) diet mouse, choline deficient (CD) diet mouse, high-fat/fructose/cholesterol (H-FFC) diet mouse and the genetically-obese (ob/ob) H-FFC diet mouse. The efficacy of the clinically effective agents elafibranor and/or pioglitazone on histological end-points, plasma parameters and liver biochemistry were also assessed.

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Animal models of non-alcoholic  steatohepatitis: comparison of the MCD,  CD, H-FFC and ob/ob H-FFC mouse

Experimental

NASH

Author

Katie R Headland, Sheila H DeWitt, Vincent Jacques, Steven Vickers, Sharon Cheetham